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Understanding surface temperature is important for habitability. Recent work on Mars has found that the dependence of surface temperature on elevation (surface lapse rate) converges to zero in the limit of a thin CO2 atmosphere. However, the mechanisms that control the surface lapse rate are still not fully understood. It remains unclear how the surface lapse rate depends on both greenhouse effect and surface pressure. Here, we use climate models to study when and why “mountaintops are cold.” We find the tropical surface lapse rate increases with the greenhouse effect and with surface pressure. The greenhouse effect dominates the surface lapse rate transition and is robust across latitudes. The pressure effect is important at low latitudes in moderately opaque (τ ∼ 0.1) atmospheres. A simple model provides insights into the mechanisms of the transition. Our results suggest that topographic cold‐trapping may be important for the climate of arid planets. 

Abstract The management of diabetes in a manner offering autonomous insulin therapy responsive to glucose‐directed need, and moreover with a dosing schedule amenable to facile administration, remains an ongoing goal to improve the standard of care. While basal insulins with reduced dosing frequency, even once‐weekly administration, are on the horizon, there is still no approved therapy that offers glucose‐responsive insulin function. Herein, a nanoscale complex combining both electrostatic‐ and dynamic‐covalent interactions between a synthetic dendrimer carrier and an insulin analogue modified with a high‐affinity glucose‐binding motif yields an injectable insulin depot affording both glucose‐directed and long‐lasting insulin availability. Following a single injection, it is even possible to control blood glucose for at least one week in diabetic swine subjected to daily oral glucose challenges. Measurements of serum insulin concentration in response to challenge show increases in insulin corresponding to elevated blood glucose levels, an uncommon finding even in preclinical work on glucose‐responsive insulin. Accordingly, the subcutaneous nanocomplex that results from combining electrostatic‐ and dynamic‐covalent interactions between a modified insulin and a synthetic dendrimer carrier affords a glucose‐responsive insulin depot for week‐long control following a single routine injection.